Cardiac MRI of Myocarditis in Adolescents after COVID-19 Vaccine

A new study in the American Journal of Roentgenology (AJR) highlights the importance of radiologists being cognizant of the association between coronavirus disease (COVID-19) mRNA vaccination and myocarditis, as well as the role of cardiac MRI for assessing suspected myocarditis postvaccination.

“In this small case series, all patients with myocarditis after COVID-19 vaccination were adolescent males and had a favorable initial clinical course,” explained first author Lydia Chelala, MD, from University of Chicago Medicine. Noting that every patient’s cardiac MRI examination showed findings typical of myocarditis from other causes, “late gadolinium enhancement (LGE) persisted in two patients undergoing repeat MRI.”

Dr. Chelala and team’s retrospective study included patients who underwent cardiac MRI between May 14, 2021 and June 14, 2021 for suspected myocarditis within two weeks of COVID-19 mRNA vaccination—without known prior COVID-19. With clinical presentation, hospital course, and postdischarge events recorded, the cardiac MRI examinations were reviewed in consensus by a cardiothoracic radiologist and cardiothoracic imaging fellow.

Of the 52 patients who underwent cardiac MRI during the study period, Dr. Chelala and colleagues identified five male patients (age range, 16–19 years; mean age, 17.2 years) who presented within 4 days of the second dose of COVID-19 mRNA vaccine. After mean hospitalization length of 4.8 days, all five patients were discharged in stable condition with improved or resolved symptoms. However, two patients underwent repeat cardiac MRI that showed persistent, albeit decreased, LGE.

Acknowledging that their article is the first report to describe additional results of short-term follow-up in this patient population, the authors of this AJR article also conceded, “the observations do not establish causality.”