Small Coil MRI of the Nipple-Areola Complex and Retroareolar Breast
By Muñoz MS, Alvares ML, Tisera DM, Muñoz ME
Imaging assessment of the nipple-areola complex and the retroareolar breast includes diagnostic mammography and targeted ultrasound as first-line imaging techniques, with magnetic resonance imaging (MRI) serving as a complementary alternative that nonetheless often leads to inconclusive results.1-6
In MRI, the sequences and coils, regardless of their brand or design, lack the necessary resolution for effective analysis of the ductal system, its contents, and the surrounding parenchyma.7
In this article, we present a practical application of focused, magnified, high-resolution MRI with contrast using commercially available small coils.8This approach is equivalent to the microfocus, spot magnification view traditionally used in diagnostic mammography. In this regard, we must discuss pioneering publications dealing with the efficacy of small coils in high-resolution analysis of different kinds of breast lesions.9
The small coil is used mainly to detect lesions not seen on standard imaging evaluation, to confirm positive findings with conventional techniques (mammography, ultrasound, MRI), and to present them in an accessible way for surgeons and the pathologists.10
Breast MRI with Small Coil Technique
The exam is performed on a 1.5T MRI scanner with a small surface coil focused on the areola instead of a conventional bilateral coil.
Owing to its design and dimensions, the small coil allows for ventral and lateral decubitus explorations according to the patient’s anatomical needs. The coil’s high performance facilitates the study of the areola and the underlying parenchyma up to a depth of 6-7 cm from the nipple, including divisions of the ducts up to the fourth grade.11
The protocol consists of T2 3D TSE (3D turbo spin echo), T1 3D FFE (3D fast field echo) and T1 3D FFE EPI (3D fast field echo-echo planar), fat-saturated sequences with and without contrast and obtained only in the axial plane. The geometry and contrast of these sequences are shown in Table 1.
The first sequence (T2 SPAIR) demonstrates ducts with serous or serosanguinous content. The second (T1 SPIR) and the third sequence (T1 SPIR-EPI) mainly detect blood products and are used before contrast administration.
After contrast injection, the second and third sequences are repeated, with the fourth sequence concluding the imaging. The fourth sequence (T1 SPIR FOV 150 mm) is optional; it has a lower resolution but a larger FOV, and provides information regarding the topography, lesion extension, and any additional findings.
Only fat-saturation sequences are applied, not only because gadolinium is used but also because the resolution provided by the coil does not require the presence of fat to identify typical lesions in this breast segment. The only artifacts are those generated by patient movement that can occur.
This is predominately a high-resolution morphological study without dynamic curves because the small coil provides images with average acquisition times of two to three minutes. The enhancement hierarchy could be visually estimated.
Regarding FOV, the software adjusts the matrix, providing 0.49 × 0.49 mm pixels with 0.7 mm slices in T2 (TSE) and 0.23 × 0.23 mm pixels with 0.6 mm slices in T1 (FF3D), with a resolution eight times higher than that of a conventional breast coil. This software also builds nonisotropic voxels that allow reconstruction in MIP (maximum intensity projection) and 3D volume rendering in the most representative planes (axial and sagittal) and video editing in three planes.12
The resolution provided by the small coil represents the anatomy of the central major ducts to detect its signal (serous, sanguineous, and mixed) and the presence of filling defects. This high resolution allows detailed analysis of enhancements of the paramagnetic contrast inside the ducts and on their walls, as well as of masses and non-masses in the surrounding parenchyma.
The protocol is primarily used to evaluate patients with clinically significant nipple discharge, palpable findings in an inverted or retracted nipple, and Paget disease.
Clinically Significant Nipple Discharge
Nipple discharge is the third-most common reason for clinical evaluation after mastodynia and palpable lump(s). The most common breast entities related to clinically significant nipple discharge are intraductal papilloma (40-70% of cases) and other benign causes.
Less frequent, but more relevant and concerning, is a malignant lesion (more commonly associated with bloody nipple discharge) that may be occult on mammography and ultrasound, such as in situ ductal carcinoma (DCIS).13,14
Papillomas are classified into central, peripheral, and intracystic types and categorized as single or multiple. Central papillomas originate outside the terminal ductal-lobular unit and are generally solitary, whereas peripheral types tend to occur in multiples, owing to their origin in the terminal duct-lobular units.15
On mammograms papillomas are usually < 10 mm, circular/oval masses, with or without associated calcifications, which can be either coarse or crushed stone-like.15
The ultrasound appearance of intraductal papilloma is a solid, vascularized nodule located within a single, dilated duct in the subareolar area. The presence of a circumscribed margin does not distinguish benign from malignant papillary lesions.16
With the small coil, central papillomas appear as measurable, solid, filling defects in a major central duct with or without gadolinium enhancement and with the most prominent ectasia in the proximal segment of the duct with varying MRI signal characteristics on T1 and T2, depending on the serous, proteinaceous, or hemorrhagic content (Figure 1, 2).17
Papillomas are characterized as single masses of different sizes and morphologies (node, bar-shaped, bifurcated, coral-like; Figure 3). Multiple papillomas (10 percent of intraductal papillomas) are often deeper, more peripheral, and occur bilaterally; they are related to hyper-
plasia, atypia, adenosis, and sclerosing lesions. They appear on MRI as random enhancing small masses not always associated with ectatic ducts. Single papillomas are rarely associated with cancer (1.3%), but multiple papillomas confer a greater risk of cancer than a single papilloma.18,19,20
Intracystic papillomas (Figure 4) are rare (1%) and frequently occur in multiples. Differential diagnosis between intracystic papillomas and intracystic papillary carcinoma is difficult preoperatively.
Other Benign Entities
There are other more diffuse, nonspecific, benign entities that allow more expectant management, including simple ductal ectasia, galactoceles (Figure 5), and fibrocystic mastopathies (Figure 6).
Normal milk ducts have longitudinal folds that disappear when the duct is distended by accumulation of fluid, cells, tumor, and detritus.21 Small coil MRI readily demonstrates distended major lactiferous ducts. Given this, the more appropriate descriptive term is “ductal ectasia” instead of “dilated duct,” as the former refers to a measurement that originated and was used in ultrasound imaging, within a range 1.0-4.4 mm.22
Depending on degree of distention and their contents, ectatic ducts can appear as filiform structures, tubular formations, or coarse cystic conglomerates in their most chronic stages. Ductal ectasia is usually an asymptomatic and nonspecific finding, but it may present with nipple discharge and is a frequent finding on ultrasound. MRI in simple ductal ectasia reveals uniformly distended ducts with fluid or serosanguineous intensity signal with normal caliber, not distorted, with or without submillimeter filling defects and without wall enhancement. MRI with small coils also helps to precisely locate the compromised segment or quadrant if surgery is required.
Breast cancer may clinically manifest with nipple inversion or retraction, a size increase and/or asymmetry on areolar palpation, as in Paget disease, or with significant nipple discharge as the only finding.
One subtype of breast cancer originating from the major lactiferous ducts presents with serous or bloody nipple discharge with a tumor growth pattern showing a mixture of papillary/micropapillary and/or cribriform growth without necrosis. No calcifications are expected on mammography in these cases, because, as Tabar indicates, “the nipple discharge prevents the long-term fluid stagnation within the duct”. 23,24,25
As an initial exam, breast ultrasound can be effective for the detection of invasive carcinomas and certain types of DCIS, including intraductal papilloma with DCIS or intraductal papillary carcinoma, which appear as masses. However, ultrasound may not be effective in detecting DCIS that manifests only with nipple discharge.
With small coil MRI, the micropapillary and cribriform growth patterns appear in discontinuous patches toward the nipple as non-mass-like regions of contrast enhancement, often in clustered rings, branching in an increasing number of abnormal ducts (neoductogenesis)25,26, with little or no contrast washout for 5-10 minutes.
Detected by MRI, these features allow for more accurate determination of their extent and anatomic location better than ultrasound, which is known to underestimate the extent of DCIS.27,28 MRI with small coils better represents segmental distribution; ie, triangular on maximum intensity projections and pyramidal on 3D volume rendering (Figures 7, 8). This finding supports previously published data that confirmed the high positive predictive value for a malignant lesion when encountering the clustered ring enhancement pattern and segmental disposition.29,30
Palpable Lesions with Inverted or Retracted Nipples
Small coil image findings may be conclusive in these clinical situations; they are primarily used to detect and characterize masses, to associate the retracted nipple with chronically diseased ducts, or to assess the need for surgical exploration (Figures 9, 10).
Once a lesion has been confirmed, either by mammography or ultrasound breast, MRI should also performed, as the modality offers a detailed exploration of the central cone of the breast (Figure 11) to search for an underlying cancer.31
MRI with small coils can provide a high-resolution targeted study (similar to diagnostic spot-magnified mammography) that can serve as an adjunct to standard techniques for evaluation of the nipple-areola complex and retroaleolar breast.
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- Berger N, Luparia A, Di Leo G, et all. Diagnostic Performance of MRI versus galactography in women with pathologic nipple discharge: A systematic review and metaanalysis. AJR 2017; 209:465-471.
- Sarica O, Ozturk E, Demirkurek H, Uluc F. Comparison of ductoscopy, galactography, and imaging modalities for the evaluation of intraductal lesions: A critical review. Breast Care. 2013; 8:348-354.
- Srinivasan A, Nia E, Gupta M, Sun J, Leung J. Retrospective statistical analysis on the diagnostic value of ductography based on lesion pathology in patients presenting with nipple discharge. The Breast Journal 2019; 25:585-589.
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- Morrogh M, Park A, Elkin E.B, King T.A. Lessons learned from 416 cases of nipple discharge of the breast. Am J Surg. 2010; 200:73-80.
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- Kanemaki Y, Kurihara Y, Okamoto K, Nakajima Y, Fukuda M, Maeda I, et al. MR mammary ductography using a microscopy coil for assessment of intraductal lesions. AJR. 2004; 182:1340-1342.
- Kanemaki Y, Kurihara Y, et al. Ductal carcinoma in situ: correlations between high-resolution magnetic resonance imaging and histopathology. Radiat Med. 2007; 25:1-7.
- Zacharioudakis K, Kontoulis T, Vella J. Can we see what is invisible? The role of MRI in the evaluation and management of patients with pathological nipple discharge. Breast Canc Res Treatm. 2019; 178(1):115-120.
- Ohuchi N, Abe R, Takahashi T, Tezuka F. Origin and extension of intraductal papillomas of the breast: a three-dimensional reconstruction study. Breast Cancer Res Treat. 1984;4(2):117-28.
- Simpfendörfer T, Li Z, Gasch C, et al. Three-dimensional reconstruction of preoperative imaging improves surgical success in laparoscopy. J Laparoendo Adv Surg Techn. 2017; 27(2):181-185.
- Lippa N, Hurtevent-Labrot G, Ferron S, Boisserie-Lacroix M. Nipple discharge: The role of imaging. Diagn Intervent Imag. 2015; 96(10):1017-1032.
- Chen L, Zhou WB, Zhao Y,et all. Bloody nipple discharge is a predictor of breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 2012;132(1): 9-14.
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- Son EJ, Kim EK, Kim JA, Kwak JY, Jeong J. Diagnostic value of 3D fast low-angle shot dynamic MRI of breast papillomas. Yonsei Med J. 2009; 50(6):838-44.
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Affiliation: Clinica Camara Gamma, Rosario, Argentina. Disclosures: None