CT-Based AI Tool Identifies People at Risk for Reduced Blood Flow to the Heart
An artificial intelligence (AI) tool is using computed tomography (CT) scans to identify patients at risk of reduced blood flow to the heart. Developed by Cedars-Sinai investigators, the tool is able to accurately predict reduced blood flow both within the coronary arteries and the heart muscle. The advantage of this AI tool is that it could potentially be used in real time during routine patient visits for CT scans to help doctors determine the next step in the treatment plan.
Investigators analyzed data from 203 patients who had taken part in a previous study, the PACIFIC trial. As part of the PACIFIC trial, all patients had undergone multiple tests within a two-week interval, including coronary CT scans, invasive coronary angiography with FFR, and heart PET scans. The researchers developed an AI tool that analyzes features of the plaques on coronary CT scans, and then predicts the probability of reduced blood flow on invasive FFR and PET scans.
This AI tool can be incorporated into routine analysis of coronary CT scans, according to the authors. Having this information on hand during patient visits could help doctors know which patients to refer for further testing, such as noninvasive stress testing or invasive coronary angiography. For some patients, this would mean avoiding invasive tests.
“Coronary CT angiogram is the first-line test for chest pain, as it allows us to measure the atherosclerotic plaque and narrowing,” said Damini Dey, PhD (https://researchers.cedars-sinai.edu/Damini.Dey), director of the quantitative image analysis lab in the Biomedical Imaging Research Institute and professor of Biomedical Sciences and Medicine at Cedars-Sinai and corresponding author of the study. “If we can integrate CTA plaque data with stenosis with AI to predict impaired FFR, we could risk stratify patients correctly to realize the functional significance of the stenosis.”
The research was published in Circulation: Cardiovascular Imaging.