AI Tool Can Improve Accuracy of Breast Ultrasounds

A new study from researchers at NYU Langone Health shows a computer program trained to see patterns in thousands of breast ultrasound images can help physicians accurately diagnose breast cancer.

When tested separately on 44,755 already completed ultrasound exams, the artificial intelligence (AI) tool improved radiologists’ ability to correctly identify the disease by 37% and reduced the number of biopsies needed to confirm suspect tumors by 27%.

Led by researchers from the Department of Radiology at NYU Langone Health and its Laura and Isaac Perlmutter Cancer Center, the team’s AI analysis is believed to be the largest of its kind, involving 288,767 separate ultrasound exams taken from 143,203 women treated at NYU Langone hospitals in New York City between 2012 and 2018. The team’s report publishes online Sept. 24 in the journal Nature Communications.

“Our study demonstrates how artificial intelligence can help radiologists reading breast ultrasound exams to reveal only those that show real signs of breast cancer and to avoid verification by biopsy in cases that turn out to be benign,” said study senior investigator Krzysztof Geras, Ph.D.

Although not generally used as a breast cancer screening tool, ultrasound has served as an alternative to mammography or follow-up diagnostic test for many women, said Geras, an assistant professor in the Department of Radiology at NYU Grossman School of Medicine and a member of the Perlmutter Cancer Center.

Ultrasound is less costly, more widely available in community clinics, and does not involve exposure to radiation, the researchers say. Moreover, ultrasound is better than mammography for penetrating dense breast tissue and distinguishing packed but healthy cells from compact tumors. However, the technology has also been found to result in too many false diagnoses of breast cancer, producing anxiety and unnecessary procedures for women. Some studies have shown that a majority of breast ultrasound exams indicating signs of cancer turn out to be noncancerous after biopsy.

“If our efforts to use machine learning as a triaging tool for ultrasound studies prove successful, ultrasound could become a more effective tool in breast cancer screening, especially as an alternative to mammography, and for those with dense breast tissue,” said study co-investigator and radiologist Linda Moy, M.D, a professor at NYU Grossman School of Medicine and a member of the Perlmutter Cancer Center. “Its future impact on improving women’s breast health could be profound.”

Geras cautions that while his team’s initial results are promising, his team only looked at past exams in their latest analysis, and clinical trials of the tool in current patients and real-world conditions are needed before it can be routinely deployed. He also has plans to refine the AI software to include additional patient information, such as a woman’s added risk from having a family history or genetic mutation tied to breast cancer, which was not included in their latest analysis.

For the study, over half of ultrasound breast examinations were used to create the computer program. Ten radiologists then each reviewed a separate set of 663 breast exams, with an average accuracy of 92%. When aided by the AI model, their average accuracy in diagnosing breast cancer improved to 96%. All diagnoses were checked against tissue biopsy results.