Percutaneous vertebroplasty: Overview, clinical applications, and current state

By McDonald RJ, Lane JI, Diehn FE, Wald JT

Vertebral compression fractures (VCFs) are extremely common, particularly in the osteoporotic population, with over 700,000 new fractures per year in the United States alone (Figure 1).1,2 The lifetime risk of a symptomatic VCF has been estimated at 15.6% for Caucasian women and 5.0% for Caucasian men.3 The morbidity of symptomatic VCFs exceeds that of hip fractures and has a comparable negative impact on quality of life as chronic diseases such as heart disease and diabetes.4 The healthcare expenditures stemming from the morbidity and disability of these fractures now exceeds $5 billion in direct costs alone from inpatient admissions and emergency room visits. Since osteoporosis is primarily a disease of the elderly and the population of individuals aged 65 and over is growing rapidly, the cost of caring for VCFs could increase 53% by 2025.5

Clinical presentation

Approximately 84% of symptomatic VCFs classically present with midline back pain. In addition, 80% of patients also reported referred pain to the ribs, hips, groin, or buttocks.6 Weakness and neurologic symptoms may also be present at or below the site of fracture, depending upon the severity and extent of compression, from effacement of the neural foramen and central spinal canal. These symptomatic presentations, which are considered to be the more severe form of VCFs, are often associated with decreased functional status, quality of life, mobility, and increased dependence on analgesics and narcotics, morbidity, and mortality.7 Pain and pain-related sequelae associated with VCFs are thought to arise from disruption and irritation of the periosteum from compressive forces on the collapsed vertebral body. In less severe cases, particularly in elderly patients with severe osteoporosis, spontaneous VCFs can occur without any pain. Regardless, both symptomatic and asymptomatic VCFs can be associated with increased morbidity arising from altered biomechanics of ambulation, loss of normal spinal curvature with progressive scoliosis, and, in severe cases, impaired respiratory function arising from exaggerated thoracic kyphosis. Pathologic VCFs often present with the same symptoms in conjunction with systemic manifestations of their underlying malignancy, including night sweats, unexplained fevers and weight loss, and diffuse bone pain in cases of systemic osseous metastatic disease.

Basics of spinal augmentation

Since the mid 1980’s, percutaneous spinal augmentations have been performed to reduce the pain, narcotic use, and disability associated with VCFs. These techniques were rapidly adopted in Europe and later in the US due to their efficacy and ease of implementation into both inpatient and outpatient settings without the need for excessive post-procedural monitoring. After initial development of vertebroplasty in 1984 for treatment of painful intraosseous spinal hemangiomas, this technique was adapted to treat symptomatic osteoporotic VCFs in 1991.8,9 Years later, the range of clinical indications for vertebroplasty has expanded further to include treatment of traumatic fractures, malignant fractures, preoperative augmentation in patients about to undergo corpectomy, post-operative hardware stabilization (Figure 2), and painful neoplastic lesions.7 Additionally, vertebroplasty is also used when there are multiple compressions when further collapse may result in pulmonary compromise, gastrointestinal dysfunction, or altered center of gravity. Additionally, kyphoplasty and sacroplasty were developed, as additional spinal augmentation techniques.10,11 These techniques are thought to mitigate the pain associated with these fractures by reducing the dynamic compressive forces placed on these compressed vertebral bodies through percutaneous intraosseous injection of a biologically-compatible polymer, polymethylmethacrylate (PMMA).12

Patient evaluation and selection criteria

Patients suffering from VCFs are typically referred though either a primary care provider or specialist to an experienced proceduralist. Patients are screened during a focused history and physical exam for criteria including a) the presence of an acute to subacute fracture (1 week to 2 years in age) as determined using clinical history and radiographic imaging; b) localizing pain with overlying tenderness that correlates with imaging; c) axial non-radiating pain; d) ineffectiveness of conservative therapies that include bed rest, analgesics, and bracing; and e) a fracture that results in a reduction of activities of daily living. Radiographic evaluation of focal back pain suspicious for VCF should begin with plain film radiographs in conjunction with MRI in order to ascertain the relative age of the fracture (Figure 3). For patients who either cannot tolerate MRI (body habitus or claustrophobia) or for which MRI cannot be performed due to technical contraindications (e.g. MR incompatible device such as a pacemaker, defibrillator, aneurysm clip), CT in conjunction with bone scan examination can serve as viable imaging alternative (Figure 4). Further, in severely osteoporotic patients, or for those with concomitant osteopenia/osteoporosis and trauma, CT is often obtained in conjunction with MRI as it is more sensitive than conventional radiographs in the detection of these more subtle VCFs in the setting of decreased bone density.

The vertebroplasty procedure

Although minor methodologic derivations exist, the key elements of the vertebroplasty procedure are outlined below.12 After acquiring informed consent, the patient is placed in the prone position in the procedure room and continuously monitored (pain, physiology) by the operator and trained support staff. Pain management usually consists of local anesthesia administered by the operator (described below) in conjunction with conscious sedation that is administered by certified support staff; general anesthesia is only used rarely in cases where conscious sedation is contraindicated or where generalized anesthesia would confer more favorable outcomes.

Using either biplanar or CT fluoroscopy, the anatomy and relative positioning of the affected spinal levels are assessed and pre-procedural adjustments are made to the imaging angles to optimize the percutaneous surgical approach. Following administration of subcutaneous and periosteal anesthesia, a coaxial needle introducer is subsequently guided down to the periosteum using fluoroscopy (Figure 5); typically 11-gauge coaxial needles are used in the lumbar spine while 13-gauge coaxial needles are used in the thoracic spine. Using the standard transpedicular or peripedicular approaches, the needle is targeted so as to traverse the middle of the trabecular bone of the pedicle, taking special care to avoid breaching the bony cortex of the spinal canal, neural foramen (Figure 6). The needle is then advanced until it terminates near the center of the vertebral body, no more than one half to two-thirds of the anterior-posterior (AP) dimension of the vertebral body, taking care to avoid breaching the ventral vertebral body cortex into the overlying anterior external venous plexus (Figure 7). Final needle positioning is confirmed and documented with fluoroscopy.

Subsequently, PMMA is activated with catalyst, mixed to a toothpaste-like consistency with a workable life of 10-12 minutes, and slowly injected into the vertebral body via the coaxial needle (Figure 8). Cement injection is continuously monitored under fluoroscopy to assess the spread of the cement and extraosseous cement extravasation. Cement injection volumes vary with the size of the compressed vertebral body and typically range from 1-4 cc with a median injection volume of 2 cc per vertebral body. Typical endpoints of the procedure include cement flow to the medial aspect of the contralateral pedicle and extension into the disc space, epidural space, or epidural veins. In cases where injected cement fails to spread into the contralateral body and pedicle, cement distribution can be optimized though needle repositioning or by use of bilateral or curved coaxial needles (Figure 9). In cases where minimal early cement extravasation is observed, the initial cement injection can be used to embolize these channels prior to injecting more viscous partially catalyzed PMMA, to help ensure intraosseous injection. As the goal of PMMA injection is to stabilize the existing fractured vertebral body height rather than restore the original height, complete filling of the vertebral body is almost never performed, and risks unnecessary extravasation and undesirable complications. After injection, the introducer needle is carefully removed, taking care to avoid PMMA deposition in the extraosseous soft tissue needle track, and hemostasis is achieved with manual compression. The patient is then observed in a post-procedural recovery setting with emphasis on monitoring vital signs, hemostasis of the needle tracks, and signs of complications (noted below).

The kyphoplasty procedure

After the relatively widespread adoption of vertebroplasty, kyphoplasty was introduced in 2001 as an alternative spinal augmentation method.11,13 The kyphoplasty method represents a variation of vertebroplasty whereby an angioplasty-like balloon is inserted into the vertebral body, and inflated to create a cavity. The cavity is subsequently filled with cement (Figure 10).14,15 Theoretically, use of this balloon mitigates the risks associated with cement extravasation that are seen with vertebroplasty. As kyphoplasty is otherwise identical to vertebroplasty and is implemented on the same spinal levels, these procedures are often viewed as interchangeable from an outcomes perspective.16

The sacroplasty procedure

Sacral insufficiency fractures, akin to VCFs, are a debilitating source of low back pain. Sacroplasty, first described in 2003, represents an adaptation of the vertebroplasty procedure to these sacral fractures.10 Preoperative planning and imaging diverges from vertebroplasty workup insofar as the physical exam is sometimes more limited, and conventional radiograph sensitivity is much lower in the detection of sacral insufficiency fractures. Early use of MRI or bone scintigraphy in the evaluation process provides a highly specific means of excluding other sources of low back pain and a useful means to classify these fractures with respect to laterality (unilateral or bilateral) which greatly aids in pre-procedural planning. Sacroplasty can be performed using either CT or fluoroscopic guidance using similar materials and techniques as vertebroplasty and yields similar benefits with respect to improvements in pain, mobility, and narcotic use (Figure 11).17,18

Postprocedure protocols

Though post-procedure recovery protocols vary, patients are typically transferred to a recovery unit and placed on 2 hours of strict bed rest in order to ensure clearance and metabolic reversal of the sedation and anesthesia administered during the procedure. During this time, the needle tract sites are inspected for hemostasis and the patient is educated regarding proper wound care over the next several days. Ambulation during this time is possible but discouraged due to the increased fall risk of these patients during the metabolic clearance of these pharmacologic agents. However, during this recovery period, the patient could ambulate if needed without risk of cement failure. After this two hour window, patients are discharged to home. If not already scheduled to do so, follow-up appointments are also made to see the patient’s primary care provider and spine specialist to better assess the long term efficacy of spinal augmentation.


The majority of complications arising from vertebroplasty and related techniques are related to unintended cement placement along the needle trajectory tract or extravasation outside of the fractured vertebrae. As spinal compression fractures are, by definition, associated with cortical compromise, the risk of extravasation is generally elevated as disruptions in the marrow cavity and overlying cortex provide a natural low-resistance outflow pathway for cement material, often flowing into the intervertebral disc space via the fractured endplate (Figure 12 A and B). Indeed, the incidence of uncomplicated asymptomatic extravasation is relatively high, occurring as frequently as 20-30% in larger case series with lower rates in kyphoplasty owing to the use of an intraosseous balloon.19 In contrast, the symptomatic complication rate of vertebroplasty has been shown to be less than 1% and most commonly consists of minor complications such as rib fracture (0.6%), pedicle fracture (0.3%), isolated infection (0.6%), hemorrhage (1%), and temporary radicular pain.20 The more serious symptomatic complications are somewhat rare, occurring approximately 0.1% of the time, and are related to cement extravasation into the epidural space or anterior venous plexus (Figure 12 C and D).21 Extravasation into the epidural space is associated with increased morbidity from nerve root or spinal cord compression; and extravasation into the anterior venous plexus can be associated with increased risk of mortality in those rare cases where venous extravasation leads to significant embolization of cement into the pulmonary arteries.22 Fortunately, the incidence of these severe forms of extravasation can be diminished through use of multiplanar imaging, particularly during needle positioning and cement injection.

Vertebroplasty vs kyphoplasty

In 2009, following the results of the two large randomized controlled trials of vertebroplasty that demonstrated some of the benefits of vertebroplasty are derived from placebo,23,24 national practice patterns substantially changed with decreases in referrals and increased utilization of conservative and pharmacologic therapy in the treatment of symptomatic VCFs.25 Notwithstanding, vertebroplasty continues to be offered to a high proportion of referred patients. Referrals continue, in part, because while these randomized trials do suggest some degree of “placebo efficacy,” post-procedural improvements in mobility and narcotic dependence are more difficult to reconcile with this notion and suggest multifactorial mechanisms of pain relief in vertebroplasty.

Numerous studies have been completed in an attempt to define advantages for both kyphoplasty and vertebroplasty. Authors have cited greater height restoration with kyphoplasty, kyphosis reduction, and a lower complication rate. However, similar results have been defined in vertebroplasty.15,26-30 KAVIAR, a randomized trial comparing balloon kyphoplasty and vertebroplasty for VCFs was published in 2014.16 This trial compared the safety and efficacy of the two procedures. In the end, no significant differences were defined between kyphoplasty and vertebroplasty. Both procedures were shown to be effective. Procedure duration was shorter with vertebroplasty. Kyphoplasty had fewer cement leakages and a trend toward longer fracture-free survival.


Vertebral augmentation remains an active technique in medical practice for the treatment of painful compression fractures. Both vertebroplasty and kyphoplasty offer patient benefit and can be completed with low risk of significant complications in patients who have failed conservative management of their spinal compression fractures.


The authors would like to thank Sonia Watson, PhD, for her editorial assistance and technical expertise.


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McDonald RJ, Lane JI, Diehn FE, Wald JT. (Jan 10, 2017). Percutaneous vertebroplasty: Overview, clinical applications, and current state. Appl Radiol. 2017; 46(1):24-30.

Dr. McDonald, Dr. Lane, Dr. Diehn, and Dr. Wald are Radiologists at the Mayo Clinic, Rochester, MN.

All figures in this article are used with permission of the Mayo Foundation for Education and Research. All rights reserved.

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