Join Bracco Imaging and Subtle Medical for an exclusive webinar exploring how cutting-edge AI is transforming contrast-enhanced brain MRI. Learn how the collaboration between two innovation leaders is helping radiologists overcome long-standing challenges around safety, efficiency, and diagnostic confidence — without compromising image quality. With the introduction of AiMIFY™, a first-of-its-kind AI solution for contrast boosting, clinicians now have powerful new tools to deliver high-quality care with greater flexibility.

You’ll hear directly from the team behind this technology — including Stanford Neuroradiologist and Subtle Medical founder, Dr. Greg Zaharchuk, Bracco medical and product experts, and Subtle’s Chief Product Officer. This session will combine clinical insight, product innovation, and real-world use cases to show how AI can enhance your current workflow, maximize the value of contrast agents, and elevate patient care — even in resource-constrained environments.

What You’ll Learn:

The strategic vision behind the Subtle Medical and Bracco collaboration.
How AiMIFY™ boosts contrast appearance without increasing dose.
A behind-the-scenes look at the AI algorithm, product development, and workflow integration behind AiMIFY.
Real clinical evidence showing improved image quality and more confident diagnosis.

Speakers

Greg Zaharchuk, MD, PhD Greg Zaharchuk, MD, Ph.D
Professor of Radiology, Stanford University
Co-Founder, Subtle Medical

Dr. Zaharchuk is a Professor of Radiology and practicing neuroradiologist at Stanford University, and a founder of Subtle Medical. He earned his undergraduate degree from Stanford, followed by a PhD from the Harvard/MIT Division of Health Sciences and Technology and an MD from Harvard Medical School.

He completed his radiology residency and neuroradiology fellowship at UCSF. Dr. Zaharchuk is a recognized expert in advanced imaging techniques, particularly for neurological disorders. He holds multiple patents, has received numerous awards for his research, and is a past president of the American Society of Functional Neuroradiology (ASFNR). He currently serves on several scientific boards and advisory committees across academia and industry.

Elena Magalotti
Global Brand Manager Contrast Management & Digital Health
Bracco Imaging, Italy

Elena is the Global Brand Manager at Bracco Imaging, where she leads the development of the company's portfolio of Digital Health and AI solutions for Radiology.

Since joining Bracco Imaging in 2007, Elena has held various roles within the Global R&D and Global Marketing functions, consolidating her expertise in developing and marketing medical devices. She holds a Master’s Degree in Biomedical Engineering from Politecnico di Milano and has completed executive education in Strategy from Oxford University.

Ajit Shankaranarayanan, Ph.D.
Chief Product Officer
Subtle Medical

Ajit is the Chief Product Officer at Subtle Medical, where he leads the company’s innovation pipeline, product strategy, engineering, and operations. He holds a Ph.D. in Biomedical Engineering from Case Western Reserve University.

Prior to Subtle Medical, Ajit served as Chief Operating Officer at HealthLytix and spent 16 years at GE Healthcare as the Global Manager for Neurology in the MR division, where he shaped the strategic vision and development of GE’s neurological MRI solutions.

Gunter Erb
Global Senior Medical Expert
Bracco Imaging

Dr. Erb serves as the Senior Medical Expert for MRI at Bracco Imaging, bringing over 22 years of experience with the company. He earned his medical degree from the University of Heidelberg and completed his residency in radiology and neuroradiology at the university hospitals of Heidelberg and Tübingen in Germany.

Throughout his career, Dr. Erb has collaborated with numerous scientific partners, contributed to several peer-reviewed publications, and delivered lectures worldwide—particularly focused on MRI contrast agents.

AiMIFY™ Software

Indications and Usage

AiMIFY is an image processing software that can be used for image enhancement in MRI images. It can be used to increase contrast-to-noise ratio (CNR), contrast enhancement (CEP), and lesion-to-brain ratio (LBR) of enhancing tissue in brain MRI images acquired with a gadolinium-based contrast agent. It is intended to enhance MRI images acquired using standard approved dosage per the contrast agent’s instructions for use.

Cautions

AiMIFY-enhanced images should not be used alone to assist patient diagnosis. The standard post-contrast image must always be reviewed first before using AiMIFY-enhanced images for patient diagnosis.

Please be aware that AiMIFY is not intended for artifact reduction, such as metal artifact and motion artifact. Enhanced images may have similar artifacts as input images.

AiMIFY may enhance intensity differences between pre-and post-contrast images that are caused by 1) registration errors between the sequences or 2) image artifacts in either sequence.

AiMIFY may enhance vessel conspicuity more than standard acquired post-contrast images. In cases where vessel conspicuity interferes with or delays diagnosis, the standard post-contrast image should be used for adjudication.

AiMIFY-enhanced images may contain false lesions due to enhancement of image quality issues in either input sequences, due to being introduced by the AiMIFY algorithm, or both. The standard post-contrast image should be used to rule out false lesions.

Please be aware that AiMIFY has only been trained and tested on head MRI for contrast enhancement. Using the AiMIFY software in other anatomies or use cases not defined in this user manual could result in unknown image enhancement performance.

The internal morphology of tissue in input sequences have been tested to be moderately preserved by AiMIFY processing both for lesion tissue and parenchyma tissue. Internal morphology may appear to be missing due to window leveling of the image, and can be obtained by adjusting the window levels.

Please be aware that AiMIFY is intended for use only with standard of care quality images. Standard approved dose contrast images should be acquired per the contrast agent’s instructions for use. The standard of care should not be adjusted in preparation for using AiMIFY.

Please be aware that AiMIFY should not be used for acquiring stat scans or emergent scans, as image processing time may delay diagnosis.

Standard approved dose contrast images should be acquired per the contrast agent’s instructions for use. AiMIFY-enhanced images are not fully equivalent to post-contrast images acquired with a higher than recommended actual dosage of contrast. However, the high-dose-like appearance of AiMIFY-enhanced images offers a potentially safer alternative to actually acquiring post-contrast images beyond standard dosing.

Contraindications

AiMIFY is an image processing software that inherently doesn’t cause harm to patients of any subpopulation. However, gadolinium-based contrast agents are associated with contraindications, precautions, and warnings for certain subpopulations. Strictly follow the gadolinium-based contrast agent’s instructions for use, including but not limited to contraindicated patient populations, prior to processing with AiMIFY.

Limitations

AiMIFY has been trained and tested using a diverse DICOM image dataset collected from different MR imaging applications at 0.3T, 1.5T, and 3.0T, including:

T1 weighted imaging for pre and post-contrast brain scans obtained with gadolinium-based contrast agents in 2D sequences, such as fluid-attenuated inversion recovery (FLAIR) and fast spin echo (FSE).
T1 weighted imaging for pre and post-contrast brain scans obtained with gadolinium-based contrast agents in 3D sequences, such as BRAin VOlume (BRAVO) inversion-recovery-prep fast split echo (SPGR) and Magnetization Prepared Rapid Gradient Echo (MPRAGE).
Acquisition in axial, coronal, and sagittal orientations.
Images acquired with GE Medical Systems, Philips Medical Systems, Siemens Healthineers, and Hitachi scanners (see separate Scanner List for models).
Images (for performance testing) spanning a variety of pathologies including patients with Cerebritis, Glioma, Inflammation, Lymphoma, Meningioma, Metastatic lesions, Multiple sclerosis, Neuritis, other tumor-related lesions (e.g., resection/radiation necrosis / suspected cyst / etc.), and other abnormalities.
Patients aged 7 to 86 years old with an even distribution of females and males in the test dataset.
Lesions in the dataset were small (<1 cc) and large (>1 cc).

Any imaging sequences/applications outside the above list may result in prolonged processing time and/or unreasonable results.

AiMIFY is manufactured for Bracco Diagnostics Inc. by Subtle Medical Inc. – Menlo Park, CA, USA 94025.

AiMIFY is a trademark of Bracco Imaging S.p.A.