Novel MRI Approach Maps Glucose Metabolism in the Brain Without Radioactive Substances
Common disease such as Alzheimer's, depression, diabetes, and cancer often have associated metabolic disorders that are detected by MRI. However, radioactive substances have been used to map glucose metabolism in the brain. A research team at MedUni Vienna has developed a new MRI approach that uses a harmless glucose solution to generate reliable results. This new method can be used with all common MRI scanners and has been published in the scientiﬁc journal Nature Biomedical Engineering.
The research team conducted a study to improve current diagnostic methods for mapping brain glucose metabolism. They measured blood glucose levels and metabolic products in healthy subjects multiple times over 90 minutes, using a harmless glucose solution instead of radiolabeled glucose. This method indirectly measured the concentrations and metabolism of glucose based on changes in signal intensity for the product. Unlike other approaches, this method does not require additional hardware components, making it easy to use with other MRI devices. Wolfgang Bogner from MedUni Vienna explained the signiﬁcance of this ﬁnding for clinical practice.
The study was conducted by researchers from the Department of Psychiatry and Psychotherapy and the Department of Medicine III at MedUni Vienna, using the university's 7-Tesla MRI scanner, which is the only ultra-high-ﬁeld MR scanner in Austria. The researchers were able to demonstrate that their new approach also works on 3-Tesla MR scanners, which are commonly used in clinical applications. This ﬁnding was an important step in validating the practicality and widespread applicability of the new method. Fabian Niess, the lead author of the follow-up study, highlighted the signiﬁcance of this development.
Many common diseases are characterized by abnormalities in glucose metabolism. For example, cancer and tumor cells consume more glucose than normal cells, which is used in diagnosing and locating tumors through PET-CT scans. However, this requires injecting patients with radioactive glucose. While the new, less invasive MRI method developed at MedUni Vienna shows promise, further studies are needed to validate its effectiveness before it can be used for patient benefit.