Hemoptysis due to pulmonary metastasis of renal cell carcinoma

By Mohammed Aladdin, MD, Cynthia Sudar Singh, MD, Renuka Gupta, MD, Kamini Giri, MD, Harinder Sawhney, MD, and Jeffrey Fischbein, MD
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Hemoptysis due to pulmonary metastasis of renal cell carcinoma

Findings

A right femoral artery approach was performed, and, subsequently, a thoracic aortogram showed no evidence of a vascular mass supplied by the bronchial artery. The bronchial artery was not visualized. However, the late arterial phase of the angiogram showed a faint tumor blush projecting on the right lower lateral chest, but the feeders were not identified. Selective catheterization of the right subclavian artery and an angiogram were performed, which showed that the mass was supplied mainly by the right subscapular artery branches. Superselective catherization of the branches of the subscapular artery was performed with a Renegade microcatheter (2.8Fr 0.93 mm; Boston Scientific USA/Medi-Tech, Natick, MA) and contrast was injected. A hypervascular mass was seen on the right lateral chest wall (Figures 2 and 3). Subsequent embolization of the mass with a total of 2 vials of 300 to 500 µm polyvinyl alchohol (PVA) was performed. A postembolization angiogram confirmed a successful embolization (Figure 4). The patient was observed for 24 hours to evaluate the frequency and severity of hemoptysis. The patient tolerated the procedure well with no evidence of complications. At 2-month follow-up, the patient had no further hemoptysis. 
 

Discussion

Massive hemoptysis may result from various causes, most common of which are bronchogenic carcinoma and chronic inflammatory lung diseases. Other causes include tuberculous bronchiectasis, lung abscess, pneumonia, chronic bronchitis, pulmonary interstitial fibrosis, pneumoconiosis, pulmonary artery aneurysm (Rasmussen aneurysm), congenital cardiac or pulmonary vascular anomalies, aortobronchial fistula, ruptured aortic aneurysm, and ruptured bronchial artery aneurysm. Diagnostic studies for massive hemoptysis include radiography, bronchoscopy, and chest CT.

 

The source of massive hemoptysis is usually the bronchial circulation (90% of cases) rather than the pulmonary circulation (5%).1 Bronchial artery embolization has become an established procedure in the management of massive and recurrent hemoptysis; its use was first reported in 1973 by Remy et al1 and subsequently reported in other cases in the literature.2-5

In a minority of cases (5%), massive hemoptysis may originate with the aorta or the systemic arterial supply to the lung, as was seen in our case.6-8 Nonbronchial systemic arteries can be a significant source of massive hemoptysis, especially in patients with pleural involvement caused by an underlying disease. Missing the nonbronchial systemic arteries at initial angiography may result in early recurrent bleeding after successful embolization of the bronchial artery. Many investigators have documented that a concerted search for nonbronchial systemic arterial supply should be made.

 

Conclusion

Massive hemoptysis is one of the most dreaded of all respiratory emergencies and can have a variety of underlying causes. In 90% of cases, the source of massive hemoptysis is the bronchial circulation.9 However, nonbronchial systemic arteries can be a significant source of massive hemoptysis. Nonbronchial systemic artery embolization is a safe and effective nonsurgical treatment for patients with massive hemoptysis. This case is a rare example of a large vascular mass in the right lateral chest wall (which was supplied mainly by a nonbronchial artery, the subscapular artery) and of successful embolization of the lung tumor supplied by the subscapular artery.

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  9. Yoon W, Kim JK, Kim YH, et al. Bronchial and nonbronchial systemic artery embolization for life-threatening hemoptysis: A comprehensive review. RadioGraphics. 2002;22:1395-1409.
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Hemoptysis due to pulmonary metastasis of renal cell carcinoma.  Appl Radiol. 

January 14, 2010
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